CBSE Class 12 Bio Technology Syllabus 2027 (Subject Code 045) has been released by the Central Board of Secondary Education for the 2026-27 academic session. It is a 100-mark course – 70 marks theory across 2 units (Unit V – Protein and Gene Manipulation, 40 marks; Unit VI – Cell Culture and Genetic Manipulation, 30 marks) in a 3-hour exam, plus 30 marks Practical. Download the official CBSE Class 12 Bio Technology Syllabus PDF and see the full unit-wise breakdown below.
CBSE Class 12 Bio Technology Syllabus 2027 PDF
The complete CBSE Class 12 Bio Technology curriculum for the 2026-27 session is embedded below. You can read every unit, chapter and practical, or download the official PDF for offline study.
CBSE Senior Secondary Syllabus 2027 Bio Technology View Download
CBSE Class 12 Bio Technology Syllabus 2027 – Marks Weightage (Unit-wise)
The CBSE Class 12 Bio Technology exam carries 100 total marks – 70 for the theory paper and 30 for the Practical. The theory paper is spread across two units as follows.
| Unit | Title | Marks |
|---|---|---|
| Unit V | Protein and Gene Manipulation | 40 |
| Unit VI | Cell Culture and Genetic Manipulation | 30 |
| Practical | Experiments, Project, Viva and Record | 30 |
| Total | 100 |
CBSE Class 12 Bio Technology Syllabus 2027 – Unit-wise Topics
Unit V – Protein and Gene Manipulation (40 marks) covers Recombinant DNA Technology, Protein Structure and Engineering, and Genomics, Proteomics and Bioinformatics. The topics included are:
Unit VI – Cell Culture and Genetic Manipulation (30 marks) covers Microbial, Plant and Animal Cell Culture and their applications. The topics included are:
CBSE Class 12 Bio Technology Syllabus 2027 – Prescribed Textbook & Practicals
Every CBSE Class 12 Bio Technology student is required to perform the following practical experiments during the academic session:
The 30-mark practical scheme of evaluation is split as: Two experiments (6 + 6 marks, only one computer-based), Practical record (4 marks), Viva on practical (4 marks), Project write-up (5 marks) and Viva on project (5 marks). More emphasis is given to hands-on work in projects.
Prescribed Books: A Text Book of Biotechnology – Class XII (Published by CBSE, New Delhi) and A Laboratory Manual of Biotechnology – Class XII (Published by CBSE, New Delhi). The NCERT Biotechnology textbook and the Class XI CBSE textbooks are prescribed as reference material.
CBSE Class 12 Bio Technology Syllabus 2027 – Exam Pattern (Assessment Areas)
The 70-mark theory paper is a 3-hour exam. Marks are distributed across three competency areas, with an internal choice of approximately 33%. The typology of questions includes VSA (with MCQs), Assertion–Reasoning, SA, LA-I, LA-II and Source/Case/Passage-based integrated assessment questions.
| Competency | Description | Weightage |
|---|---|---|
| Demonstrate Knowledge and Understanding | State, name, list, identify, define, describe, outline, summarize | 50% |
| Application of Knowledge / Concepts | Calculate, illustrate, show, adapt, explain, distinguish | 30% |
| Analyse, Evaluate and Create | Interpret, analyse, compare, contrast, examine, evaluate, discuss, construct | 20% |
| Total (Theory) | 70 Marks |
CBSE Class 12 Bio Technology Syllabus 2027 – Continue Your Preparation
Once you have reviewed the syllabus, practice with the CBSE Class 12 Bio Technology Sample Paper and previous years’ CBSE Class 12 Question Papers to prepare for your board exam.
Frequently Asked Questions
The CBSE Class 12 Bio Technology Syllabus 2027 (Subject Code 045) is the official curriculum released by CBSE for the 2026-27 academic session. It has two theory units – Protein and Gene Manipulation (40 marks) and Cell Culture and Genetic Manipulation (30 marks) – for 70 theory marks, plus 30 practical marks, totalling 100 marks.
The subject code for Bio Technology (Biotechnology) in CBSE Class 12 is 045.
The CBSE Class 12 Bio Technology theory paper is of 70 marks (3 hours), plus 30 marks for the Practical, making a total of 100 marks.
CBSE Class 12 Bio Technology has two units – Unit V: Protein and Gene Manipulation (40 marks), covering Recombinant DNA Technology, Protein Structure and Engineering, and Genomics, Proteomics and Bioinformatics; and Unit VI: Cell Culture and Genetic Manipulation (30 marks), covering Microbial, Plant and Animal Cell Culture.
The prescribed books are A Text Book of Biotechnology (Class XII) and A Laboratory Manual of Biotechnology (Class XII), both published by CBSE, New Delhi, with the NCERT Biotechnology textbook prescribed as reference.
CBSE Class 12 Syllabus 2026-27 (All Subjects)
You study more subjects besides Bio Technology in 12th class. The subject-wise syllabus for CBSE Class 12 students is as follows.
CBSE Syllabus 2026-27 (Class-wise)
The class-wise syllabus for CBSE board students is as follows.
CBSE Class 12 Bio Technology Syllabus 2027 – An Overview
The important things to know about this curriculum are as follows.
| Aspects | Details |
|---|---|
| Education Board | CBSE |
| Class | Class 12 |
| Subject | Bio Technology (Subject Code 045) |
| Study Material Here | CBSE Syllabus for Class 12 Bio Technology |
| All Curriculum for This Class | CBSE Syllabus for Class 12 |
| All Curriculum for This Board | CBSE Syllabus |
| Full Name of CBSE | Central Board of Secondary Education |
| NCERT Books | NCERT Books for Class 12 |
| NCERT Solutions | NCERT Solutions for Class 12 |
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